The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease

Blog Article

Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes.The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as Silicone Straws a neutrophil chemoattractant.In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability.Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair.

We argue that PGP functions as a primitive and conserved damage-associated molecular pattern, which is generated during infection or injury and subsequently acts to shape ensuing inflammatory and repair processes.As a fragment of the ECM that accumulates at the epicentre of the action, PGP is perfectly positioned to focus neutrophils to the exact site required and direct a localised repair response.However, it is essential that PGP is efficiently degraded, as if this matrikine is allowed to persist then pathology can ensue.Accordingly, we Waterproof Bodywarmers discuss how this pathway is subverted in chronic lung diseases giving rise to persistent inflammation and pathological tissue remodelling.